For the Fallout series, bugs, crashes, glitches, save bloat etc are actually normal and in fact the feature that is commonly associated with the Fallout series.
Anyway, after installing the latest patch, I played it quite well, disregarding the twice the random crashes and load issues. Thing is, after a few days, them crashes managed to evolve into the Ultimate Unplayability Patch.
What happen here is that, after a while the crash gets more and more frequent, and now every time I loaded a save, it triggered a time bomb with the range of 2-10 seconds before crashing for good. Tried without mods, no cigar. Validated? Yes. Reinstall? I hope not.
This effects all saves, including new characters.