Okay, so every time I play FNV (and FO3 to a lesser extent) I run into inventory management problems - specifically, that I frequently end up overencumbered. This seems to happen whether I have a carry capacity of 170 or 250, and no matter what build I use. It's part of the reason I always always use two companions (one humanoid, one robot) even when it would have made more sense to go alone. It's also why Strong Back is a perk that I take in every single playthrough, even with the limited amount of perks available, and I've taken the Long Haul perk whenever possible. For RP reason I tend to keep a proper armor for combat (say, combat armor), 'wilderness' apparel and 'formal' apparel. I suppose this contributes to the problem, as does the fact that my ammo has weight because I play on 'hardcoe' mode.

I'd guess that it's also because of how I loot - I tend to take all weapons, armor and food items whenever I kill someone. This has always been how I played games with loots and inventories. I've always assumed that this was the way to play, but it recently struck me that I pretty much never read of people complaining about not having enough inventory. I personally find it quite disruptive to have to stop midway through killing some Fiends/Legionaries and have to fast travel to a vendor.

So how do you guys organise your inventory and decide what to loot and what to discard? Or do you just svck it up and frequently interrupt your dungeon-crawling to make vendor trips?

I never really have that problem in New Vegas very much because I always pump up repair and take Jurry Rigging, that way when I'm finished with a fight I can use most of the stuff I just looted to either repair my own gear or repair something I know I can get a lot of caps from that I just got. It helps me keep my carry weight at a reasonable number, I still get to sell my loot for a lot of money, and all my toys are in perfect shape.

jurry rigging FTW!

But, what do you do with the rest of the loot, after your weapons and armor are in full condition? With high repair especially it won't take much to restore your equipment to full condition.

Take the weapons, leave the armor. Any small loot i usually carry and sell.

You do have a homebase where you're dumping your stuff right? You can't expect to carry around everything you find over your journeys on your back! Also, Pack Rat is an amazing perk for hardcoe as it lets you carry twice as much ammo effectively.

Besides the other good advice about jury rigging and triaging what kind of stuff to loot and sell, I never bother with any kind of loot that doesn't sell for at least 20 caps once you get to a vendor. There's a crapton of junk out there that sells for 1, 5, 10 caps... and weighs a LOT once you start picking up any amount of it, collectively. Avoid the low-price junk, and save a lot of weight for better stuff. It makes no sense to end up with half your pack full of widgets and thingamabobs that weigh 100 pounds and sell for a few hundred caps total, when you can use that same amount of weight to take back a dozen weapons that are worth 1000 to 5000 caps *each*, or more. So, dump those beers and drop the toasters, and just keep stuff that sells great and keeps ya killin' longer!

i use the trailer behind good springs store and carried a wooden crate inside of it, it has two metal boxes, one metal box to put stuff that needs better repair to get better value and the other metal box to store weapons i want to keep but im not using at the moment.
the wooden crate i dragged inside is used to store stuff that has been repaired to a good enough condition to sell off.
once i get enough goods in the wooden crate, i load myself and my two companions up with the loot and go visit the many merchants to make some caps.

I simply set my cw to 50000 so that there's no need to pause and visit vendor. In addition I add jury rigging in the beginning via console command.
But stashing is still recommended since if you carry alot, opening pip-boy takes longer.