No, the non-lootable flag was an invention for Oblivion, in attempts to nerf the game by not letting you pick up things you can clearly see. Morrowind allows you to pick up items.
You can remove all instances of an item from the player, which makes it very difficult for them to loot. That's reasonably simple.
You can put a script on items to not allow them to be picked up, which will work if they're in the world, but not in another inventory.
You can force the player to drop items whenever they're added to the player's inventory.