Really? Ok then I'm skipping explosives! That's a relief! BTW hardcoe mode is just kinda annoying! I don't mind it but damn everytime I travel or take a nap it's back to Goodspring Source for some water
It gets easier as you go. You don't get rads from drinking out of toilets anymore... so anytime you see one just drink up.
If you raise survival skill then cooking meat will grant you all the food you ever could want. If you don't just pick up food in people kitchens... not that hard.
Sleep is something that almost never gets called up. I go 3 to 4 full day/night cycles before needing to sleep... don't sleep till you need to.
Honestly the only time for me when it became a problem is when you wait/skip time. I only travel after dark to make the most out of my low sneak skill so I am always waiting during the day...
Also on a side note I almost died of thirst on my first play threw because I never notices that Sunset Sasparirla actually makes you thirstier... I just kept chugging 'em wondering why it was not working...