So This is probably foolish, But I have played all of the fallout games and not once have I seen a Vault meet a good end unless I was from the thing.
The Fiends Vault (Vault 3) in NV and the Vault 92 in 3 Really spring to mind.
I'll Stick to Vault 92 for this.
I was doing the quest Agatha's Song in Fallout 3 and I'm stumbling around the Vault I'm level 12 on hard so the Mirelurks are just demolishing my health bar and I go sprinting into a bathroom.
Well I'm waiting for my health to regen, (I've got two Stim-packs but I'm saving them for crippled limbs) using this mass of food I've been picking up for awhile. and while I wait I do my stall check, in which I basically go down the line of stalls in a bathroom open the doors and search the toilets and any bodies for loot.
I get to the end.
It's not a stall.
It's just a gap between a stall wall, and the vault wall itself.
Crammed in that gap
A little skeleton and a teddy bear.
I have a bit of an imagination, I stopped. And all I could actually see was this kid running from mommy and daddy 'cause they don't love him or her anymore, and they've cornered him or her and the child just can't understand.
I started crying. I'm 21, I'm a Jaded Cynical berk, and I cried.
If anyone with input for the Design of Fallout 4 reads this please let us have the option of saving a Vault. Maybe they're being attacked by Raiders. Maybe the Reactors are failing or a slaver guild is slowly pushing into the Vault.
I get that the Vaults Represent old world corruption. But let us avert at least one bad end for people who shouldn't have had to fear.