Ok so I always enjoy being evil in Fallout and as a result I like my karma level to be perpetually evil.
My problem is getting good karma for killing insta-hostile enemies.
I sided with the Powder Gangers and when I kill the hostile Gangers I still get good Karma.
It's stupid to get good karma for killing something you basically HAVE to kill.
Same with the various Raider gangs.
The Vipers and such.
I don't think you can side with them in any way.
Same with the fiends, but I may be wrong.
And good karma for killing a feral ghoul?
Wtf is that?
I hope this gets patched but my gut says it won't.
Just like the invisible walls.........
If I want to climb up a cliff to avoid getting killed by a Giant Radscorpion at level 3, THEN I SHOULD BE ABLE TO!
Does this bother anyone else?

Yeah, It is rather different than the previous fallout 3, oh well, what can you do? Still no patch, so who cares....