The F5 key seems to be disable!!?? I had to re-bind the quicksave to the F4 key!! FYI

It seems like you have a lot of issues judging from this and other threads. I know it isn't the best option, but maybe you should reinstall the game. Before you do, if you chose to do so, make sure you have deleted anything left over from mods you may have installed.

Make sure you back up your saves. Let the new install create the the other files in your games files in documents.

lmao i just quicksaved before "modifying" my settlement (i do that often) & thought meh so i quickloaded & all of the sudden it loaded up some save that was days old?? da faq