I use the number keypad (to the right of the main keyboard) for movement (4 and 6 left and right, 5 and 2 forward and back) which leaves me just enough keys to bind the limited number of options we have here and it works great.
Numpad 0 - Weapon Swap
Numpad Decimal - Ultimate
Numpad 1 - Ability #1
Numpad 3 - Ability #2
Numpad 7 - Ability #3
Numpad 8 - Ability #4
Numpad 9 - Ability #5
Numpad Divide - Inventory
Numpad Multiply - QuickSlots
Numpad Minus - Generic "Windows" (the ALT default key)
Numpad Plus - Crouch
Numpad Enter - Jump
I DO have to use Delete for Synergy and END for "interact".... but they're not far (go go pinky finger!)... I just use F for interact with player and H for mounting horse, and W for Walk-Toggle and Backspace for sheathing weapons, since I don't need those RIGHT NAO.
I also remap the Dialog Controls for primary/secondary/tertiary/decline, although I can never remember the exact order... ONE of them, and I think it's ~secondary~ dialog option, for some reason, is the LOOT ALL option, which I bind to END, so I hit END to loot a foe and then I can hit END immediately and it'll LOOT ALL (but I still get to see what I'm looting in the window ---- I don't like the AUTO-loot feature).
In a way, having limited button-presses HELPED me... in other games, I bind the numpad as much as I can but then I still have to leave my movement keys and reach over to some other key.
EDIT: Oh, I forgot, I also bound the thumb button on my mouse to switch First and Third person view. I don't use a fancy multi-button mouse