I think "we must preach the holy gospel of natural progression", of course.
In all seriousness, the OP deserves a fair warning that this game is more fun if you don't rush. More fun to me anyway. Doesn't mean it's the same for him, he wouldn't be asking how to powergame if it was, but it's still something to consider. Other RPGs usually have much different levelling systems, so effects of powergaming aren't as noticable until later and even then they're not gamebreaking. But overdo it in Skyrim and you quickly turn it into a boring grindfest.
My lockipicking characters didn't fare significantly better than those who didn't lockpick. There's plenty of good loot to be found outside chests. I didn't say that lockpicking doesn't help at all, just that it has a smaller impact on your combat prowess than other skills.
We can one-shot dragons because of a combination of stealth bonus, weapon skill and crafting. A basic steel dagger in the hands of level 8 character won't one-shot any bosses.
What I meant though is that Sneak level 100 doesn't make you OP in and of itself. Assassin's Blade does, but it's available at 50 Sneak and by this time you already have ways to make your movement very quiet, so you don't really need another 50 levels. You should be acquiring a good blade and the skill to wield it instead. Not to mention practical experience in sneaking, because powerful backstabs are useless if you lack tactical sense and stupidly alert all enemies in the area.
Tbh, I don't think it's entirely true. It has a grain of truth, more like. Minmaxing upsets the game balance, sometimes it makes you stronger (crafting synergy), sometimes weaker (I'll try again, Speech. Please don't tell you can prove that Speech makes you an excellent warrior.
) In the end it's not worth it - again, in my personal opinion.