I'm running an ASUS P6T Deluxe mobo and using on board sound. I've noticed that I hardly CTD at all with the radio off. With it on, I may get one or two CTDs on average during a two to three hour session of game play.

Anyone else notice this?

Yeah i noticed it too. I′m also using a ASUS mobo and the integrated sound, not the same model though.

Could be a sign to troubleshoot the installed codecs.
Also update your chipset drivers, and soundboard drivers.

A thread to get you started: http://www.gamesas.com/index.php?/topic/1131535-falloutnv-has-stopped-working-ctd-after-20-attempts-to-fix-it/

I'm pretty much a stickler for keeping all my drivers up to date. Thanks for the link.