Mastering a skill tree and mastering a perk tree might be different. The most powerful perks or most desirable perks to you
might not have anything to do with the others. Ten skills with 5 perks in each could be an interesting choice if the five perks build on each other so you get one high level perk in each skill.
That being said, I doubt I'll get to level 50 with my first character and I tend to specialize and stay at low levels.
I lean towards thief characters, but if they do some really cool stuff with some of the perks from other archetypes I think I'll try those skills out and have a mix to figure out what I like best.