Can anyone take a look at my load order and offer suggestions on any troublesome mods before I invest too much in a game?

Update.esmUnofficial Skyrim Patch.espDawnguard.esmUnofficial Dawnguard Patch.espHearthFires.esmUnofficial Hearthfire Patch.espDragonborn.esmUnofficial Dragonborn Patch.espSkyrim Project Optimization - Full Version.esmFalskaar.esmWyrmstooth.espApachiiHair.esmApachiiHairFemales.esmETaC - RESOURCES.esmRSkyrimChildren.esmSkyTEST-RealisticAnimals&Predators.esmWinterholdDestruction.esmNock2Tip.esmInn Girls Resources.esmHighResTexturePack01.espHighResTexturePack02.espHighResTexturePack03.espUnofficial High Resolution Patch.espCutting Room Floor.espBrawl Bugs CE.espfFastTravelSpeedMult_4.espGuard Dialogue Overhaul.espWeapons & Armor Fixes_Remade.espETaC - Complete.espWetandCold.espTamriel Reloaded HD.espimmersive roads.espExpandedWinterholdRuins.espAOS.espETaC - Dragon Bridge South.espClothing & Clutter Fixes.espCollegeOfWinterholdImmersive.espPurity.espComplete Crafting Overhaul_Remade.espdD - Realistic Ragdoll Force - Reduced.espRaceMenuPluginXPMSE.espDisease Descriptions.espDD_Dawnguard Additions.espDD_Dragonborn Additions.espiHUD.espChesko_LoreBasedLoadingScreens.espSkyUI.espTradeBarter.espImmersive Jewelry.espSDO Full-LOD - The Morthal Swamp Complete.espJKs Skyrim Major Cities.espSkyrim Immersive Creatures.espImmersive Orc Strongholds.espHelgen Reborn.espETaC - Complete EWDR Patch.espSkyFalls + SkyMills + DG + DB + FS + WT.espUndeath.espImmersive Wenches.espLessIntrusiveHUD.espAMatterOfTime.espAchieveThat.espDual Wield Parrying_SKSE.espHothtrooper44_Armor_Ecksstra.espRaceMenuMorphsUUNP.espYOT - Your Own Thoughts.espThunderchild - Epic Shout Package.espSkyrim Immersive Creatures - DLC2.espImmersive Whiterun.espImmersive Solstheim.espCidhna Mine Expanded.espPerkusMaximus_Master.espPerMa Expansion 1 - Wintermyst.espPre PaMa WAFR CCOR Patch.espImmersive Sounds - Compendium.espISCompendium CCO Patch.espAMB Glass Variants Lore.espDifferently Ebony.espPerkusMaximus_Mage.espimp_helm_legend.espBetterQuestObjectives.espBook Covers Skyrim.espRemove Interior Fog V2 - Full Version.espdawnguard sentries.espFeminine Females.espImmersive Weapons.espWeaponsArmorFixes_ImmersiveWeapons_Patch.espHothtrooper44_ArmorCompilation.espLaundry.espBellyachesNewDragonSpecies.espCults of Skyrim.espSDO Full-LOD - Waterfall Effects.espfallentreebridges.espPre PaMa SiC Patch.espaMidianborn_Skyforge_Weapons.espDYNAVISION Dynamic Depth of Field.espSMIM-Merged-All.espCWINPCApachiiSkyHair.espCWIDawnDragonPatch.espLostGrimoire.espVivid Landscapes.espDragon Combat Overhaul.espDual Hand Combo Hotkeys.espGQJ_DG_vampireamuletfix.espMoonGlow.espBeards.espDSAMG - Miraak Music Fixes.espDSAMG - Greybeard Fix.espRSChildren - Complete.espRSChildren_PatchUSKP.espGuardAnimationsGDO.espDr_Bandolier.espETaC - Complete RS Patch.espHarvestOverhaul.espHarvestOverhaulCreatures.espCharacter Creation Overhaul.espCCO - Diverse Races And Genders.espCCO - Dynamic Skill Progression.espCCO - Oblivion Carry Weights.espNPC Knockout Overhaul.espAtlas Legendary.espImmersive Patrols II.espETaC - Complete CRF Patch.espSDO Full-LOD - Whiterun Trundra Creeks.espPatronGodsOfSkyrim.espSFO - Dragonborn.espBook Covers Skyrim - Lost Library.espLPBards.espThrowing_Weapons_Redux.espCCO - Permanent Birthsigns.espPerkusMaximus_Warrior.espPerkusMaximus_Thief.espSinderionsLabRedone.espSkyrim Flora Overhaul.espWheelsOfLull.espPilgrimsDelight.espThe Paarthurnax Dilemma.espArgonian Access.espBetter Dynamic Snow.espETaC - Better Dynamic Snow Patch.espMoss Rocks.espSneak Tools.espPreventsAccidentPickUp.espSneak Tools Vanilla Hoods.espSaveHotKeyMCM.espDuke Patricks - Skyrim Friction Fix.espEK_RingLimiter.espExtended UI.espTheCoenaculiUNP.espNo Killmoves, No Killcams, No Killbites.espWondersofWeather.espdD-No Spinning Death Animation Merged.espAHZmoreHUD.espBetterQuestObjectives-AMBSkyforgePatch.espBetterQuestObjectives-CRFPatch.espBetterQuestObjectives-PaarDilemmaPatch.espImmersive detection of NPC.espAuto Unequip Helmet.espMainMenu.espImmersive Music Temples.espFantasy Soundtrack Project.espImmersive Music.espDragonPriestMaskQuestMarkers.espUnique Grasses.espSkyTweak.espiCompass - Immersive Compass.espSmartCast_1_0.espiActivate.espWyrmstooth - PerMa Patch.espPerMa_USKP master patch.espPerMaExtendedPerkDescriptions.espBetterQuestObjectives-PerMaPatch.espThunderchild - PerMa Compatibility Patch.espPerMaSneakQuietCasting.espPerMaSoulEmbroidery.espCiceriareplacor.espTrueStorms.espKaceAutoloot.espWetandCold - Ashes.espRaceMenuNails.espBretonnia - BRETON PRESETS 1-10 by FastestDog.espRaceMenu.espRaceMenuPlugin.espISCompendium AOS Patch.espNock2Tip.espTrueStorms-Purity.espAOS2_Purity-patch.espAOS2_Purity Patch.espDuel - Combat Realism.espSkyRe Artifacts.espSneak Tools Vanilla Masks.espBrevi_MoonlightTales.espSDO Full-LOD - Giant Campfires.espThe_Sinister_Seven.espForgottenMagic_Redone.espISC PerMa Compatibility Patch.espForgottenMagic_Redone_PerMa Patch.espspelleraser.espAOS2_WAF Patch.espPM_flesh_spell_fix.espPermArchery_ALL_R.espSplitEnchantRank2.espAlternate Start - Live Another Life.espBetterQuestObjectives-AlternateStartPatch.espBashed Patch, 0.espASIS-Dependency.espPatchusMaximus.espPost PatchusMaximus Perma Mods and Tweaks.espASIS.espEveryBody's Different.espAutomatic Variants.esp