I was a lone wolf in Fallout 3. With Skyrim, I tended to run around with a companion more often than not, but still ended up being a lone wolf most of the time. Depending on what types of followers we have and what their dialogue is like, I might actually try to keep a friend close for my play through. That said, if some of what I've seen is correct, there is a nice perk for the lone wolf players...
I'll probably end up mixing it up moreso in FO4 than I ever have before.