That would be cool. I loved the mood in the Pitt, it was almost like being in a city right after the bombs had gone off.
I liked the Pitt aswell and I never could fathom why Bethesda didn't expand on it more. It could of been the best DLC of the bunch. Missed oppurtunity.
And from Dead Money we know Avellone like it aswell.
Lonesome Road looks different from my imagination though. I did expect harsh winds, desert storms, ect. But also large cyclone-like effects and large thunder strikes with the tone almost as dreary as Fallout 3.
But in a way the difference wouldn't of been much different than walking around Zion Park when it's storming. Just a little less subtle if they went that route, but this way it's a noticeable change.