I did a bit of digging but that didnt turn up much. What I am looking for is kind of a "second playthrough", which resets not only respawns of monsters (theres plenty of mods doing that) but also the reset of all containers/item placements etc ingame. Quests are not required , but it would be interesting to know if the item replacement can be done.
If anyone of you knows of such a mod - just drop a line.

Roaming the wastelands
Shaya