Alright, so I got GOTY a few months ago on Steam and everything worked great. Over the past few days I've installed quite a few mods some of which are pretty big (MMM, EVE). Everything was running smoothly yesterday but now all of a sudden I can barely play without the game crashing. I tried rewriting the .ini line that seems to work for everyone but unfortunately not for me. I'm really hoping someone here can give me a hand. As always, here is my DxDiag:

Here is my DxDiag:

------------------
System Information
------------------
Time of this report: 1/12/11 7:23
Machine name: STEVE-PC
Operating System: Windows 7 Home Premium 64-bit (6.1, Build 7600)
Language: English (Regional Setting: English)
System Manufacturer: ASUSTeK Computer Inc.
System Model: G60VX
BIOS:Default System BIOS
Processor: Intel? Core?2 Duo CPU P7350 @ 2.00GHz (2 CPUs), ~2.0GHz
Memory: 4096MB RAM
Page File: 1623MB used, 6564MB available
Windows Dir: C:\Windows
DirectX Version: DirectX 11

------------
DxDiag Notes
------------
Display Tab 1: No problems found.
Sound Tab 1: No problems found.
Sound Tab 2: No problems found.
Sound Tab 3: No problems found.
Input Tab: No problems found.

---------------
Display Devices
---------------
Card name: NVIDIA GeForce GTX 260M
Manufacturer: NVIDIA
Chip type: GeForce GTX 260M
DAC type:Integrated RAMDAC
Aprox. Total Memory: 2799 MB
Current Mode: 1366 x 768 (32 bit) (60Hz)
Monitor Name: Generic PnP Monitor

Driver Name: nvd3dumx.dll,nvwgf2umx.dll,nvwgf2
Driver Version: 8.15.11.8631
Driver Date: 7/2/2009 12:59:00 AM
WHQL Logo'd: Yes
DDI Version: 10
Driver Model: WDDM 1.1
DirectDraw Acceleration: Enabled
Direct3D Acceleration: Enabled
AGP Texture Acceleration: Enabled

-------------
Sound Devices
-------------
Description: Speakers (High Definition Audio Device)
Hardware ID: HDAUDIO\FUNC_01&VEN_10EC&DEV_0663&SUBS'
Manufacturer ID: 1
Product ID: 65535
Type: WDM
Default Device: Yes
Driver Name: HdAudio.sys
Driver Version: 6.01.7600.16385 (English)
WHQL Logo'd: Yes
Date: 7/13/2009 7:07:00 PM
Other Files:
Driver Provider: Microsoft

Description: Digital Audio (HDMI) (High Definition Audio Device)
Hardware ID: HDAUDIO\FUNC_01&VEN_10EC&DEV_0663&SUBS'
Manufacturer ID: 1
Product ID: 65535
Type: WDM
Default Device: No
Driver Name: HdAudio.sys
Driver Version: 6.01.7600.16385 (English)
WHQL Logo'd: Yes
Date: 7/13/2009 7:07:00 PM
Other Files:
Driver Provider: Microsoft

Description: Digital Audio (S/PDIF) (High Definition Audio Device)
Hardware ID: HDAUDIO\FUNC_01&VEN_10EC&DEV_0663&SUBS'
Manufacturer ID: 1
Product ID: 65536
Type: WDM
Default Device: No
Driver Name: HdAudio.sys
Driver Version: 6.01.7600.16385 (English)
WHQL Logo'd: Yes
Date: 7/13/2009 7:07:00 PM
Other Files:
Driver Provider: Microsoft

-------------------
DirectInput Devices
-------------------
Device Name: Mouse
Attached: 1
Controller ID: n/a
Vendor/Product ID: n/a
FF Driver: n/a

Device Name: Keyboard
Attached: 1
Controller ID: n/a
Vendor/Product ID: n/a
FF Driver: n/a

Device Name: Microsoft eHome Infrared Transceiver
Attached: 1
Controller ID: 0
Vendor/Product ID: 0x045D, 0x006D
FF Driver: n/a

Device Name: Microsoft eHome Infrared Transceiver
Attached: 1
Controller ID: 0
Vendor/Product ID: 0x045D, 0x006D
FF Driver: n/a

Device Name: Microsoft eHome Infrared Transceiver
Attached: 1
Controller ID: 0
Vendor/Product ID: 0x045D, 0x006D
FF Driver: n/a

Device Name: Microsoft eHome Infrared Transceiver
Attached: 1
Controller ID: 0
Vendor/Product ID: 0x045D, 0x006D
FF Driver: n/a

-----------
USB Devices
-----------
+ USB Root Hub
| Vendor/Product ID: 0x8086, 0x2939
| Matching Device ID: usb\root_hub
| Service: usbhub
|Driver: usbhub.sys, 7/13/2009 7:07:09 PM
|Driver: usbhub.sys, 7/13/2009 7:06:23 PM

------------
PS/2 Devices
------------
+ Standard PS/2 Keyboard
| Matching Device ID: *pnp0303
| Service: i8042prt
|Driver: i8042prt.sys, 7/13/2009 6:19:57 PM
|Driver: kbdclass.sys, 7/13/2009 8:48:04 PM
+ Microsoft eHome Remote Control Keyboard keys
| Matching Device ID: hid\irdevicev2&col05
| Service: kbdhid
|Driver: kbdhid.sys, 7/13/2009 7:00:20 PM
|Driver: kbdclass.sys, 7/13/2009 8:48:04 PM
+ Microsoft eHome MCIR Keyboard
| Matching Device ID: hid\irdevicev2&col06
| Service: kbdhid
|Driver: kbdhid.sys, 7/13/2009 7:00:20 PM
|Driver: kbdclass.sys, 7/13/2009 8:48:04 PM
+ Microsoft eHome MCIR 109 Keyboard
| Matching Device ID: hid\irdevicev2&col07
| Service: kbdhid
|Driver: kbdhid.sys, 7/13/2009 7:00:20 PM
|Driver: kbdclass.sys, 7/13/2009 8:48:04 PM
+ Terminal Server Keyboard Driver
| Matching Device ID: root\rdp_kbd
| Upper Filters: kbdclass
| Service: TermDD
|Driver: i8042prt.sys, 7/13/2009 6:19:57 PM
| Driver: kbdclass.sys, 7/13/2009 8:48:04 PM
+Microsoft PS/2 Mouse
| Matching Device ID: *pnp0f03
| Service: i8042prt
| Driver: i8042prt.sys, 7/13/2009 6:19:57 PM
| Driver: mouclass.sys, 7/13/2009 8:48:27 PM
+HID-compliant mouse
| Matching Device ID: hid_device_system_mouse
| Service: mouhid
| Driver: mouhid.sys, 7/13/2009 7:00:20 PM
| Driver: mouclass.sys, 7/13/2009 8:48:27 PM
+HID-compliant mouse
| Vendor ID, Product ID: 0x046D, 0xC043
| Matching Device ID: hid_device_system_mouse
| Service: mouhid
| Driver: mouhid.sys, 7/13/2009 7:00:20 PM
| Driver: mouclass.sys, 7/13/2009 8:48:27 PM
+ Terminal Server Mouse Driver
| Matching Device ID: root\rdp_mou
| Service: TermDD
| Upper Filters: mouclass
| Driver: termdd.sys, 7/13/2009 8:45:55 PM
| Driver: semouse.sys, 7/13/2009 7:00:20 PM
| Driver: mouclass.sys, 7/13/2009 8:48:27 PM

------------------------
Disk & DVD/CD-ROM Drives
------------------------
Drive: C:
Free Space: 92.6 GB
Total Space: 268 GB

Drive: D:
Free Space: 7.32 GB
Total Space: 29.1 GB

--------------
System Devices
--------------
...not sure where to locate this..

I'll also include my Load Order:

[x] Fallout3.esm
[x] Anchorage.esm
[x] ThePitt.esm
[x] BrokenSteel.esm
[x] Point Lookout.esm
[x] Zeta.esm
[X] EVE.esm
[x] Mart's Mutant Mod.esm
[X] FNNIguana.esm
[x] Enhanced Weather - Rain and Snow.esm
[x] Xepha's Dynamic Weather.esm

[x] Night Vision Sunglasses.esp
[x] Realistic Death Physics.esp
[x] MTC Wasteland Travellers.esp
[ ] MTC Wasteland Travellers (Optional)- Crowded Cities.esp
[x] MTC Wasteland Travellers (Optinal)- Crowded Cities less NPCs.esp
[X] EVE.esp
[x] Delay ThePitt + Anchorage.esp
[x] DelayAnchorage.esp
[x] DelayThePitt.esp
[x]DelaySteel.esp
[x]delaypl.esp
[x] delayzeta.esp
[x] Mart's Mutant Mod.esp
[x] Mart's Mutant Mod - DLC Anchorage.esp
[x] Mart's Mutant Mod - DLC The Pitt.esp
[x] Mart's Mutant Mod - DLC Broken Steel.esp
[x] Mart's Mutant Mod - DLC Point Lookout.esp
[x] Mart's Mutant Mod - DLC Zeta.esp
[x] Mart's Mutant Mod - Natural Selection.esp
[x] Mart's Mutant Mod - Tougher Traders.esp
[ ] Mart's Mutant Mod - Zones Respawn.esp
[x] Mart's Mutant Mod - Master Menu Module.esp
[ ] Enhanced Weather - Rain and Snow in Fallout.esp
[ ] Enhanced Weather - Radioactive Rain and Snow Plugin.esp
[x] Enhanced Weather - Sneak Bonus during Storms.esp
[x] Enhanced Weather - Weather Sounds in Interiors.esp
[x] Xepha's Dynamic Weather - Main.esp
[X] Xepha's Dynamic Weather - Anchorage.esp
[X] Xepha's Dynamic Weather - The Pitt.esp
[X] Xepha's Dynamic Weather - Broken Steel.esp
[X] Xepha's Dynamic Weather - Point Lookout.esp
[X] Xepha's Dynamic Weather - Rain.esp
[X] Xepha's Dynamic Weather - Sandstorm.esp

I really hope I provided enough information. Any help at all will be greatly appreciated.

It might be a mod related.
I don't know but deactivated any weather mods and see.

if you played the vault part without problems and the game crashes in somewhere in wasteland you can try that:

i hope this works for anyone more, theres thousands of people with the same problem.
and by the way after that i had a new bug, if someone could help me ...
http://www.gamesas.com/index.php?/topic/1160582-fo3-runs-ok-but-my-controls-freeze/