Call me lame, but I'd love to be able to clean up garbage and make an area look nice. If it's there, I want to be able to pick it up and recycle it or something. Just as long as that's not the game's main premise. I don't want Skyrim to be like EcoQuest or Eco-Saurus. That would be funny, but no.
YOU'RE LAME! (jk but he DID tell me to, I think he/she is a gentleman/lady and a scholar)
True, it should never be the point of the game. Ever times a million. But I love all the clutter in the game, it makes the world feel real. And honestly the only time you will ever experience any negative effects is if you somehow move hundreds of items at once. I would like to see more use for some items though. Seeing how we get smithing, to make leather or fur armor I would assume you need pelts, this would also be a place to add a potential need for wool, cloth, yarn, etc.