I really dislike the look of normal revolvers both in game and real life. In FNV, the exception to this rule is That Gun/5.56mm pistol. In real life, the sole exception is http://airbornecombatengineer.typepad.com/airborne_combat_engineer/2006/05/mateba_model_6_.html. I'd kill to have one of those in game. Probably would kill to have one IRL, too. It's the Holy Grail of handguns.
As for in game, a rapid fire, heavy caliber, balls-on accurate revolver that looks cool? Yes please.
ADDENDUM: Fallout: New Vegas needs the .454 Casul. A pistol with a bore large enough to give it's wielder the Terrifying Presence perk when it's drawn.