An explosives build, with heave ho and mad bomber, is very effective. Since you won't be using energy weapons or guns, their ammunition can be broken down and made into grenades. The MFCs can make MFC grenades in the hundreds, and the guns ammo gives powder and lead to make satchel charges and tin grenades (providing you have the other materials around). This gives you hundreds of throwables, and the ability to *really* launch them.

Boom.

Best mad bomber recipe imo is The MFC Cluster. Just scavenge all the Duct Tapes and Scrap Electronics you can find. MFC Cluster is like 6 independent throwable mines that do extreme damage. When they do not explode, you can recollect them as MFC grenades.

For an explosives build I'd always use all weight related perks (Strong Back, Burden to Bear, Pack Rat, Heavyweight and the Hoarder perk).