I'm just curious, is there a way to somehow complete the game if you've been made an enemy of all three factions? I know the final solution is most likely Yes man. But one would still need to get back into the Lucky 38 and kill Mr. House. I was just curious if anyone has checked this out or if the game is just stuck and is in-completable without relying on Yes man. I'm on my fourth run through and I've made enemies of most everyone.

its just yes man at that point, major ending factions you can side with are NCR, House, Legion, and yourself (yes man)

Be impolite, be inefficient, have a plan to piss off everyone you meet.

Fixed for you

http://www.youtube.com/watch?v=92PNiNsdths
That contradicts the inefficiency.

You alas cannot piss off Mr. House too and complete the game, becuase you have to kill Mr. House if you don't side with him. And if you piss off the Legion and the NCR, then your option is only Indy.

I always wondered why you absolutely MUST kill House unless you decide to side with him. Sure, it's the only logical thing to do, but still :shrug:

What happens if you kill Mr. House, Ambassador, Caesar and Yes Man?

House stays dead. Amby stays dead, but the leader during DamWar is General Oliver. Caesar stays dead but the leader during DamWar is Lanius. Yes Man simply reloads from backups, jacks another Securitron, and comes back to life.

Indy is literally the last resort for an ending if you piss off everyone else. You cannot kill Yes Man. You cannot piss off Yes Man either, he just says he deserves it and do it again because he deserves it more.

you can't kill yes man. he just transfers to a new body when you try.

House controls Vegas. Whoever controls Vegas and the dam controls Mojave. Logic triumphs.

Making you feel dirty for doing it in the first place.