Also, I know some people are going to say,
"Thats not harder, thats just restricting"
But I think that it makes the game more challenging.
1) I can't use VATS.
2) I can only carry 1000 rounds total.
3) I can't have a ridiculous amount of weapons, only 4, 2 pistols and 2 rifles.
4) I can only have one set of armor,
5) I can only have one point in Endurance and Strength, but I can get the bobbleheads.
6) I must eat and drink every in-game night, if not, I must consider myself dead and reload my previous save.
7) I can go 3 days without sleep, if I do, I must eat and drink more, if I go for a whole week without sleep, I die from exhaustion, reload previous save.
8) I must subtract 50 pounds from my carry weight, unless I am using power armor.
9) I can only specialize in one weapon type, small guns, energy weapons, or big guns, I can use them, but I can only put points into one.
10) Final rule, I can use either melee weapons or unarmed as a backup fighting skill.
If you want, add your own, but otherwise, please comment.