Maybe it could be used as an extra choke point if you get an invasion. If you make it 3 rooms wide you could have 6 extra armed dwellers in there.
its a security thing.. you should always have at least 1 person in all rooms.. remember a fire/radroaches can spawn in any room so having a guard to deal with the situation will prevent it from spreading to all adjacent rooms..
for example say your storage area was empty and a disaster spawned there and you had 4 rooms adjacent to the storage room... those 4 rooms could all get the disaster as well possibly killing a bunch of people in the process when if it was guarded it could have been stopped.
Yeah I had a storage room with no one in it and it caught on fire.
I have found that if roaches/fire spawn in a room and nobody is in it, it just spreads to a couple of other rooms around it. For fires it's not really an issue, but can be a pain with roaches. I certainly haven't seen any consequences of fire or roaches to the vault.... wonder what happens if you send all your dwellers exploring and leave the roaches/fire to roach/burn?
I've been only arming the two door guards with all the rest of the weapons in storage. If I get a radroach attack I just send the closest dwellers to the invaded room and equip them with weapons on the way there. Same thing with a fire. I've never been unable to get them there before the fire/roaches spread. Of course I don't have any empty rooms without a full compliment immediately next door.