Survival: Leave at base, it's useless unless you are on hardcoe, you will never ever ever ever ever ever ever need it. Poisons for a melee weapon? Really? If peircing strike, unstoppable force, superslam, and stonewall aren't enough... you should never pick up a melee weapon... use guns or something. It might be useful to get to 30 to magazine it to 50 for some recipes on HC but honestly you find food and water all over the place.
Hell, survival is useless even on hardcoe.
All it affects is how much health you get from food (ok, use stimpaks instead. I walk around with ~75 without trying)
And it affects how much food/h20 boost/fix you get from food. (ED-E or other chars work great for holding ~5-10 purified water and gecko steaks, or Maize, or other stuff)
The only really useful thing to it, if you care, is the Animal Friend perk.
hardcoe.... isn't.. not really, but it's a nice addition. But survival is really pretty useless.
As for my current build.
S 7
P 4 (with glasses based perk, +2 per glasses and beret, it's up to about 7 or 8 anyway)
E 3
C 4 or 5 (don't recall)
I 10
A 10
L 1
Lets see, I've got lockpick effectively 100. (the +4 total per boost means I only tend to have it at like 86 or the like)
Guns is ~80, likely get it to 100 by end.
Repair is 90 (for jury rig. use magazines to get Match Load .50 cal... but just pumped out ~150 .308 JSP rounds. Sniper rifle and 1-3 shots wipes out deathclaws easily)
Science 84 (thanks to skillbooks)
Sneak 55 (60 thanks to NCR Scout combat armor (or whatever it's called)
Medicine 52
Speech is... around 80 or 90. Initially I used up most of the skill-mags early due to many quests.
Barter is maybe 30.. (hence why using so many speech mags, as barter was too low even WITH the barter-mags)
EW 5
Unarmed 8
Melee 10?
Explosives 30
Survival i think is 20... only because i was considering going for Animal Friend (wife loves how cute the geckos are)... But it's such a wasted skill compared to others, I only put about 1-2 points in it per level (getting 17 skill points/lvl)
Pretty much this char can shoot, talk and hack her way out of anything...
As for weapons... right now it's a modded Sniper Rifle (actually works better than the Gobi.. weighs less (with CF parts), has suppressor, and does more damage), and the 12.7mm Pistol. (with silencer so far)
Using Boone and ED-E.. Though I do have a Thermic Lance that's fully restored in the Novac hotel room safe for when I swap to Veronica a bit later