So i have a weird problem, i get missing mesh markers and purple textures without having missing meshes or textures. Textures flicker between purple and random textures when moving the camera, missing mesh error on weapons disappear when re-equipping a weapon, the rest appear randomly too.

I got this lessened by reducing plugins, currently 135 active, and i 'm only seeing the texture bug in the pip-boy glove of the player character now. Also using the 4GB loader (Win7 x64, 8GB RAM), so i don't think this is caused by lack of memory for the game or too many plugins (254 max?).

So, what could cause this?

It's too many mods. Unfortunately, NV doesn't seem to be as tolerant of huge load orders as FO3 and OB are. Around 130 plugins seems to be the upper limit for many people with some hitting the limit around 80. I personally can't go over 80 without issues whereas in FO3 it's no problem for me to have 200. 4GB, Stutter remover, nothing helps once you hit whatever your limit is aside from removing mods.

Merge as many things as you can with Bash, combine your individual clothing and weapon mods yourself and try to get below 130. It's a pain, I know. I finally gave up on the thing and went back to Skyrim >.<

I was afraid that was the case. I do have plenty of weapon mods that i could merge into single plugin, need to learn do that then.