Simply put.
Listen to Confessor Cromwell
If what he says is true people will die, but you will create life where it never existed before.
The needs of the many outweigh the needs of the few.
Megaton = 15 - 24 people? Blowing it up = trillions upon trillions of new universes.
Just for visual sake:
24
vs
1,000,000,000,000 (1 trillion)
Moral justification for the destruction of megaton.. you're welcome Capital Wasteland.