I imagine there would be contraband of many types but as in most wars corruption reaches into the highest places of society and gets to the point where money can buy your way in or out of anything and the drug traders would have more to worry about from bandits and and the other side attacking their shipments in a country torn in two during a civil war. local officials that are short of manpower would have little reason to be concerned about the drug trade during this time but it would be fun to have quests involving a war on drugs and smugglers I guess.
In the construction set It would interesting to have NPCs that you can check as a druggie, with varying costly habits, no money for drugs, attitude and aggression factors and desperation moves such as a sneaky sudden attack with knife or axe halfway through his Spare Change speech " Please Sir help my poor wife and starving ki... Smash! You get hit with a mace and it's lights out and you wake up robbed.
Or vary it with a band of drug crazies with zombiac determinism. Either way you have to hunt down the druggie to get your Important family heirloom that coincidentally you were carrying around that night.
If you want it back. that could lead you into a fearsome feud between the two top drug cartels of Skyrim . This in turn leads you into some drug running quests to 'prove loyalty' and move up the cartel faction while figure out through cunning and clever subterfuge causing them to destroy themselves through in-fighting and you then become a crown witness for the prosecution and are exonerated by a big wig for all previous misdeeds and become a palace favorite and move up the hero scale leading to more honorable quests.
But don't use the term druggie in a quest as the term wasn't coined until 1968 when it was used to visually and audibly link the drug word to the term hippie.