*LOL* Wow. Looks like I touched a nerve here with everyone! The way I see it, if there's going to be senseless carnage, six, drug use and profanity, some juvenile humor would be the least of the ESRB ratings that Obsidian and Bethesda would have to worry about!
Just cause there is senseless carnage, six, drug use and profanity does not mean that the series don't have any self-respect.
You want "lulz" then play Borderlands, Saints Row and Postal, I've played all three and recommend them both for their "who gives a [censored]" humor and their gameplay.
But Fallout is not that and should not be changed into that either.
It'd be like asking for COD to change into Team Fortress. (Which I have not played but from the looks of it it has a lot of humor in it.)
[edit]
Didn't like the above part so let me try it a different approach.
Take two:
While Fallout has a lot of ridiculous things like robots with brains in them, a man with a tree growing out of his head, and big green ogres that scratch their ass and sniff their fingers afterwards the difference is that it's taking itself seriously.
Like, all of it is of course completely ridiculous, but the series has a dark undertone to it and works these ridiculous things so that they aren't "as" ridiculous as they appear to be at first glance.
Including the humor you stated on the other hand will cheapen the dark undertone and just make the series seem schizophrenic, one time it's dark with raiders stringing up humans in chains and cutting off their limbs while having six with their carcasses and the next it's Family Guy humor all over the place.
It stops being consistent.