Well put

But don't forget her constant complaining about "it's so bright out here,how do you stand it?"

Oh shut up already you were the dummy that gave yourself to a Daedric lord,and you are the same dummy for making yourself my follower weather I want you there or not,so can it women Gheez

Followers in general are annoying, I prefer soloing it.

Barbas and the ghost of Lachance

any Dunmer follower.

Serana "Yes. did you need something?"

Me "NO shut the hell up! You walked up to me while I was thoughfully crafting you a nice dagger but you know what? After about the 30th time you asked me that in a row... You know what? I'm going to walk up to the top of the Throat Of The World and toss this thing off the top! Hopefully you'll dive after it!."

Serana "Oh. is someone there?"

Me "No! and for the last time stop rasing the dead! I killed them for a reason! Stop bringing them back!"

Worst follower ever because you can't dismiss her until your done the DLC.

Dark brotherhood initiates apparently don't understand the concept of personal space, they may as well be sat on my knee

They're all annoying because they're made up of soft, fleshy material. I can't throw fireballs with them sitting in the fray..Atronachs for the win.

Ya Serana gets first place from me for doing this.

Serana.

Considering your avatar, this post makes me laugh.

Mjoll, god she just doesn't get it does she?

All of them svck, really. 9 outta 10 times I play a sneak character, so followers are more of a hinderance than anything else. But if I have to pick one, it would be Mjoll... She doesn't shut up, even if I'm already talking to someone else, I have to hear how she made a dude soil his amour. WTF shut up! She is a beast though, when she is all decked out, I don't think there is a stronger melee follower.

Serana. I never tried to keep Barbus for longer than it took to do that quest. I do wish the dogs had been done better, actually stop the barking and I'd be ok with them.

Sadly this is mostly true.

What is it about her in specific detail that annoys you?