Sure, in Skyrim you can run up and hack/bash them continuously until they fall over and die, all the while being caught on fire and bitten, or you can shoot them from a distance, taking damage as he Shouts on you, or do the same thing with spells.
Thing is, they're not very logical ways.
In a world where Skyrim's magic existed, but realism was taken into account (as in, being Yol Toor Shul'ed will kill you), what would be the most logical method to actually kill a dragon?