I chose Blade as the most useful, I chose Speechcraft as the least useful in the Main poll, and in the vanilla game.
For the question? Illusion is more useful than Merchantile overall, but in vanilla Merchantile is better than Speechcraft.
I have to add that I play a game built around FCOM, Race Balancing Project, LAME, and Integration. I actually have to invest in Speechcraft to play, but my vote reflects my opinion of the usefullness of Skills in an unmodded game.
The Security mini-game is an annoyance, and the skillset becomes pointless after a certain quest.
I chose Blade as the most useful because a Mage and a thief can always carry a dagger for backup, and the game does not have a decent selection of Blunt weapons that are light and fast.