1. Werewolves
2. Less dumbing down of the PC version for consoles
3. Crossbows being added, Spears would be nice too.
4. Awesome weather system, complete with fog, many different levels of rain, thunderstorms, snowstorms etc.
5. Werewolves
6. Vampires
7. Actual expansion packs, not 2-3 hour DLC like what Fallout has.
8. Big improvements on how stealth works, the way stealth worked in past elder scrolls games was just silly. Even how it worked in Fallout was pretty pathetic to be honest, I would snipe somebody from the darkness and their friend would turn around, pull out their gun and say something like "Must of been the wind" then walk straight over their dead ally, put their gun away and go to sleep.. seriously? Big improvements should be made there.
9. Did I mention werewolves? Werewolves are a must.
10. Better AI. AI has always been a weakpoint in Bethesda's games in all aspects and I'm really hoping for big improvements here.
What would you guys like to see in Skyrim?