Please let me know what your most wanted is and post it here.

My personal most anticipated game is GTA V.

No love for Diablo 3?

And it's probably not going to be 2012, but I'll be waiting for Doom 4.

Doom 4 will hopefully be way better than RAGE. I have my doubts that the ID tech 5 will be suitable for a new DOOM title.
Diablo 3... will be interesting...but iam more the kind of gamer that prefers the EGO-perpective.

I really look forward to dear esther (once a mod for halflife 2) this game will really push the limit of what the actual source engine has to offer. http://dear-esther.com/

Also Metro last light will be a must buy for me. (the metro 2033 and 34 books are two of my favorite books) http://metro.thq.com/

I would love to see more from the Deus Ex series in 2012 but i think they need more time to develop such a brilliant game like Deus Ex 3 Huma revolution. But a remake of Deus Ex 1 would be fantastic.

Diablo 3 is going to be the best game for the next 10 years.

Diablo 3 is going to be the best game for the next 10 years.

Except the Counter Strike series I have never heard of a PC game still popular after 10 years.