I have gone back and spent some time playing Fallout 3 and Fallout: New Vegas as of late to keep from going insane while waiting for Fallout 4 (although I probably am already). While I think New Vegas is a better game overall (particularly the DLC), Fallout 3 totally kicks its butt when it comes to cool things you can do on a bad karma playthrough.
(Spoiler Alerts?)
Blowing up Megaton is something really really awesome you could do right at the start of FO3. Its epicness went down in gaming history, and you got a fancy house to boot. Being a big meanie also got you access to a few quests in Paradise Falls, a small chunk of content those lame-o goodie goodies coudn't do. Heck, you could team up with slavers in Fallout 2, they gave you a nifty tattoo and some nice caps for peddling those tribals. If you were lucky enough to be playing the U.S. version of the game, you could do "something" to those wicked little "somethings" who kept stealing your stuff. However, If you sided with Ceaser's Legion in NV, you never really got to do anything cool. Being able to consign Arcade Gannon to a life of slavery and a sore sphincter was kind of fun, but not blow up a whole city fun. You could blow up the Brotherhood of Steel bunker, but there was no benefit from it. Watching Cass get vaporized by the Van Graffs was pretty much the only thing that brought a smile to my face, but I could just vaporize her whenever I wanted to. New Vegas didn't even have bad karma exclusive companions like Fallout 3 did, just some narrow-minded comanidiots you would need to kill for not understanding your (correct) point of view.
(I shouldn't have put a spoiler alert, it would have been more evil!)
So let's toast a glass of Roentgen rum, gorge on human flesh, and raise the horns for EVIL! Who else is looking foreward to playing Fallout 4 as a certified scourge of humanity? I am very excited at the twisted possiblities the team at Bethesda has likely cooked up for us.