I picked Nora for several reasons.
1. She is voiced by Courtenay Taylor. I love her voice and I am most familiar with her voice from Mass Effect 2 and 3 where she voices Jack/Subject Zero. Every time I pick an angry or sarcastic response in Fallout 4, I hear Jack from Mass Effect.
2. Nora's background gives her the least likely chance of surviving the wastelands. Not because she is a woman, but because she is a lawyer. Her familiarity with combat and weapons may possibly be from what she learned from Nate. So for me it feels like more of a challenge for her to survive. Nate might not feel at home in the wastelands but his training would kick in. I know its not any more difficult in reality to play Nora vs Nate and its just all made up in my head... but it makes sense to me.
3. I enjoy playing female characters.