1) Should I use LOOT with New Vegas, instead of BOSS?

2) WMX or WME? Which one conflicts least?

3) Should I mess with A World Of Pain? Last time my game went crazy on the lag, and i didn't use any texture mods. Since i stabilized skyrim so much so that i downloaded virtually every HQ texture mod available and it worked flawlessly with my rig, i'm now going to test out New Vegas again. But I'm seriously worried about AWOP and the numerous reports of problems. I can make patches and tweak in FNVEdit, so i'm hoping someone is using FOOK, PN modules and AWOP together that can answer if its worth it.

4) This is a question that I really don't want to ask, but i can't really stick my head in the sand either. I absolutely love Quest mods, and I want to start the game with as many as possible. I know that some people frown upon this, as it can clearly cause problems, especially later on in the game. Is there any Quest mods I should avoid? Or should I really just make a hard save, back it up, add the Quest mod, play, then revert? I really don't like the idea of the latter, but i nerfed my Skyrim b/c of one quest mod, and it didn't cause problems until about 50 hrs in, then i crashed at a few particular places.