You won't be able to install the game, but you can play from disc. Unfortunately this means you'll probably suffer from more performance based glitches. That goes for a lot of games, and 4GB is not large enough for most (any?) games to install. It will also limit the number of add-ons and saved games you can have on your drive at any one time, though it should be sufficient to have all of the FO3 add-ons installed at once. If I were you I'd shell out the extra $100 to get the 250GB xbox.