When all else fails use the wiki. It helped me alot with Fallout1.
I swear by Per's walkthroughs:
http://user.tninet.se/~jyg699a/fallout.html
http://user.tninet.se/~jyg699a/fallout2.html
Restoration Project:
http://hem.bredband.net/darek1/f2rp_wt.htm
But wiki ain't bad either.
Doesn't Jules tell you all about the families and who to talk to when you talk to him?
For a price.
I am trying my best not to just go on murdering rampage and kill all the 4 families for their lack of respect and arrogance. What do I loose actually? A few experience? I can gain that all with a centaurs random encounter.
Rampaging is also an option. Experience points is not an issue indeed you can get that anytime, although most quests provide a nice experience boost. From the top of my head what you will miss is reputation, goes for good & evil because there are good families and bad. Some rewards like discounts (See reputation: Made Man) in shops, brothels, free beer/drugs, weapons (early legal access to some laser weapons without stealing or killing for it), a few rare items maybe and caps of course. Getting your car pimped (although you can achieve this without family interaction but it definitely can come in handy). Furthermore some of the storyline plus semi-important quests intertwined with other towns like NCR, Vault City plus an Enclave encounter. I'm not exactly sure but you might also fail to interact and/or recruit an important npc who works for the Mordino's thus failing the related Jet quest/storyline.
Being made man is not necessary btw I completed the game lots of times without this reputation by finishing the family quests to a certain extend - it only matters, like in Fallout New Vegas, for the ending sequence which faction you have chosen or what not.
Also, I say: "semi-important quests" because even without completing all of this you'll still be able to finish Fallout. There are no quests that will stop you from ending the game or something like that. So rampaging is a very viable option. Heck, why not? Go for it - Kill'm all! :flamethrower: :bolt:
However you can liquidate most bosses in an intelligent, fun and more sneaky way - Without blowing the whole town up. It doesn't involve explosives (Well, only for one boss an explosive trap is an option without reverse pickpocketing), firearms or stabbing weapons.
Examine their medical conditions. :whisper:
In a nutshell: the biggest thing you'll miss out on is perhaps story-wise.