Serana's glitched my game good. This is my first post and it's a desperate one. Apparently people get Serana (from Dawnguard DLC) glitching so that she disappears or won't follow etc, I've had no problem with that, but my problem is a lot more game destroying... She won't stop wanting to take orders. I found myself telling her where to stand, she wasn't walking to where I wanted properly so I pressed the A button a lot in a mild frustration, then the special moving cursor stayed on permanently it says "wait there" permanently on my screen or "attack that guy you really just want to talk to" ....... I can't open my own doors, I can't talk to my friends around town, I can't pick up any goods.. You know it's funny how many dragons I encountered whilst not being able to loot (stupid vampire girl and her arrogance). I've been forbidden to do anything but roam the plains and hint wildlife and ugly people, and of course I can't bippity boppity boo the magic letters in to change things like on a computer so I'm stuck, someone save me!

That sounds pretty bad. Have you tried turning off the Xbox console and reloading the game? If that doesn't work, reload a saved game before this started happening (if you have one).