No longer is it wise to fight all willy-nilly, as the current slow heal plus the danger of disease from creatures such as mole rats makes things interesting. The Glowing Sea will be a huge challenge now, as there are no settlements or cities to stop for supplies, and it is extremely dangerous and full of disease-causing bugs.
Thinking about this stuff only makes me more excited for survival mode, and I'm already planning routes for my wasteland expedition.
Is there any strategies any one else is planning?