There still might be multiple endings...in fact, I'm sure there will be. I don't really see it as killing my role-playing either. If something happens at the end of the game that significantly changes the landscape it might be very difficult to allow people to continue playing. It sounds like they're also making changes to the way characters are developed that might compel me to play again with another character anyway. :thumbsup:
Larry confirmed multiple endings at 26:56.
Exact quote from Podcast "26:29 -26:56":
""No, no. There will be an ending to the game. It will be definitive if by- if they're talking about being able to beat the game, have the ending, and then go back and um see the world after the end. We won't do that in the core game, we will have a definitive end. Uh that said there will be multiple, there will be multiple endings to the game." - Larry Liberty
Now, maybe this is just my personal interpretation of his words, but it sounds like he's saying there will be a definitive end in the sense that the game actually ends the storyline, but not a definitive end in the same way as Fallout 3 had done it.
Also, did ANYONE other than myself actually take the time to listen through the entire podcast? Larry does speak quietly at some portions of it, and some portions seem downright inaudible [with Larry], but overall you can hear him pretty good, and it's the best way to get the actual information [from the firsthand source I mean].