A game set in Akavir, Thras, or Pyandonea could all make extremely interesting games and add such a great deal to the lore. Have any of the developers ever mentioned anything about possibly exploring the other continents in future games?
Or maybe a game where you are setting out on an expedition from Tamriel to explore one of these continents? It would make grounds for a great story and a series of interesting additions to the lore.