I have the problem that the plugins for my active modes dont stay checked...they are in the mod manager - but as soon as i start fallout 4 the first time, they do get unchecked... i than have to switch out of fallout 4, check them again, back to fallout 4, quit the game, restart the game - and then it works...

I have tried setting the fallout plugin file for the system to "read only" as was suggested in another topic but this didnt seem to help...

any other tips?

yeah i was told to use Fallout 4 script extender....so thats what im gonna try and see.

Do you have the latest version of the mod manager?

yup

Manuell install always works, i had the same Problem with Nexus.

Nexus Mod Manager works fine and Mod Organizer 2. Sorry to say, but Mod Manager don't worka anymore.

The Mod Manager dos not get any updates anymore, cause the creator don't want to do it anymore, cause the other two are working.

So to keep it short you should use another Mod Manager, cause your is an obsolete one.

The way i understand it the latest official patch did something somewhere thats causing this....i was told to use f4se till its fixed to launch the game and so far it seems to me to be fixed.