I just started this game today, so I don't have much advice to offer. Depending on where you are (or if you intend to restart):
-Don't underestimate the bat.
-Use the environment when in the open. Stay near rocks and large objects so when enemies attack in groups, you can jump up or run around and form a plan of action.
-Running from a fight is better than losing supplies. It didn't take me long to learn this lesson!
-Repair your armor first, your weapons second. Those DP points are priceless!
-If you get to Megatron, stay away from the saloon. Instead:
-: Talk to the old man at the water treatment plant. If your repair is high enough, he'll ask you to stop 3 leaks in town. Once you complete this, he'll offer to buy any scrap metal you find.
-: Talk to the girl at the supply store and start the Survival quest(s). Be careful, though: these aren't easy quests. I went in order of the minefield, drugs and food, and am now doing the radiation. The first gives you the opportunity to walk away with the sniper rifle, which comes in very handy for the second quest. This is a very tough fight, but you can walk away with one sweet boomstick.
-Whenever you find a bed, clear the area asap. Sleeping will be your greatest ally in the game early. One hour will restore your health, and can save on using up critical supplies.
-Don't waste skill points on barter, sneak, or speech this early. Lockpicking and repair are going to be more powerful early. Too bad I didn't realize this sooner, now that I'm just level 3.
-Repair your armor first, weapons second. The DP rating is going to be critical, and the higher, the better. The vault (escaping) offers the best armor at level 1 with the armor security outfit and the helmet. Get them and put them on. The second best armor I've seen doesn't come until the meds and food run given in the Survival quest. Aesthetics is not something to focus on early.
Well, that's all I have. Now that my game's better since my decisions screwed up my last game. By the way: SAVE. SAVE. SAVE. SAVE.
Kill something? Save. Walk 10 feet without dying? Save.
Enjoy the game.