Your topic is more than a little vague. If you want hints on a specific aspect of the game you should have specified, if you just want general hints you'll probably be better off reading through threads or checking out the http://fallout.wikia.com/wiki/Fallout_Wiki. We don't need a thread for general hints as we have an entire forum for such things, which makes this thread rather redundant.
ummm, sorry what closed thread. EDITED. I put this under hints and cheats, I asked for a hint
Don't try to do everything with a single character, between the varied skill/perk loadouts and the various main quest paths FONV is great for multiple-playthroughs. Attempting to do it all with a single character may result in the game dragging as your extremely powerful character takes on quests that are beneath them.