The more I have time to think about it, the more problems I have with the supposed beginning to Fallout 4. Now, I will be forthright and say I know next to nothing about the lore of Fallout, so if I say something or assume something incorrectly, feel free to let me know.
Basically, I do not like the idea of having 200 unaccounted years in between going to sleep and waking up in the Wasteland. The most basic reason being that there are only so many ways to account for such a time lapse. I think at this point, anyone familiar with information Bethesda has presented is assuming cryogenic sleep, and to me, that would be absolutely fine. But, Fallout is a universe that has a lot of strange stuff in it (if Fallout 3 is anything to go by). Being frozen to awake later doesn't bother me. Secretly being an android does. Or being a part of some dream experiment or possibly something even stranger, maybe Matrix-like. I know we don't really know much about how the game kicks off and in that regard, it is hard to say what may or may not happen. However, the fact that they seem so concrete with the 200 years we know will pass between the games introductory sequence and the earnest beginning of the gameplay, makes me think that there is something obviously critical to the beginning of the main story.
A lot has been made about customizing your wife/husband and how it will affect your child's looks. The general consensus is that your son at the very least will play some important part in the game, but some (myself included) believe or want to believe that your wife will survive as well. However, as you are labeled the Sole Survivor of your vault, that means that a. they died prior to getting into the vault, b. they died in the vault, or c. they are MIA upon... however you survive the 200 years, and are presumed dead. Now, I respect the developers and am excited to be able to experience the story they have created, however, the move they are making with this 200 year time lapse reminds me a bit of ME2.
-ME2 spoiler alert-
I have the same fear that this is what is going to happen in Fallout 4. I just want to be a human guy, without any weird circumstances surrounding my existence. I would like to be able to continue with the family unit you start the game with, but I understand if the story structure prevents that. I just hope that this was a natural development of making the game and that it isn't forced in their just to accomodate being able to see the pre-war era and then live in the post-war fallout era. I don't want it to come off as a Mass Effect 2 beginning, if you know what I'm trying to get at.