I can't wait to see Jon from Many a True Nerd attempt an "You Only Live Once" run of Fallout 4 like he did with New Vegas and Fallout 3.
You can be walking along in Fallout 4 and suddenly be clocked in the side of the head by a mininuke fired from a skyscraqer walkway far above you, or peek your head out around a corner just in time to catch a molotov right to the face. Last night, I was clearing the Corvega Plant, and was down to one raider on the highest tower. I am for his head, hold my breath, and squeeze off a shot, just as he throws a grenade ... which my bullet hit, just as it got close .... blowing me up instantly.
Funnily enough, however, this morning I accidentally ran into a minefield, and as soon as I heard the beeping, I just starting RUNNING. And then there was an explosion, and more beeping, and MORE beeping, with mine after mine exploding behind me as I triggered more and more of them, staying JUST ahead of the blasts. Bethesda is devious in where they place mines in Fallout 4. Much more hidden and realistic. And deadly.
Not so much fun for those playing dead is dead. Personally I do like how the game will get just the right enemy combo and straight up turn me into a blood stain though. Keeps me on my toes.