Just a little south west of Coyote mines and a little north of Searchlight North Gold Mine, there's a ghoul standing relatively close to a tree, and there's also a friendly marker by where it stands. After killing the ghoul I went to inspect this friendly in V.A.T.S and my game froze. After a reboot, I actually had a walk around the area and there are no NPC's there but the marker is still showing. I've repeated the glitch around 5 times now and each time I've had to reboot my Xbox.
In V.A.T.S mode, a health bar shows up with around 2-3 bars left of health but no name comes up with it. Even selecting Boone and ED-E first then scrolling through V.A.T.S causes the crash.