I've played through the whole game multiple times on both PC and 360, yet I have never encountered a problem such as this. Every time I go to talk to an NPC, the game crashes. I can't figure out how to fix this. I'm on a PC, but have no mods (I'm not exactly computer savvy, so I've never been able to figure them out). This all happened sort of randomly. One second, everything was normal, the next, I couldn't talk to anyone. It's happening on ALL of my saved games, and even on ones I created after the problem began happening. The last quest I was on was "Go Fish". I was about to complete the quest by talking to Aelwin, and that's when the game first crashed. Any and all help is much appreciated.

You are asking the question in the PC forum, with the lack of information that would be suitable to a console game question. When you are ready to actually provide sufficient data to work with, only then will anyone here be able to answer anything.