On every playthrough when I get the Megaton house I kill Wadsworth before he can even say anything. Well, not this last time, this time I just shoved him in a corner, shut his ai off through the console and shrunk him by 50%.
I havent started any collections on this character, but the usual collections are Nuka-Cola trucks, full beer bottles ( I usually fill the sink up then start scattering them arond the house), or cartons of cigarettes.
I also play "shoot the gnome". You take one gnome, set it on something so that it will be slightly higher than your eye level when you crouch (your weapon should be at about a 45 degree angle when aiming at it). Crouch down, pull out a shotgun, shoot gnome. Then go look for it, sometimes they fly so far away I've never found them again