Yes. They are cast from the top down. The wiki is wrong on this. There was a thread on this a few weeks ago, where I posted some detailed examples of why. Might be difficult to find it, but if I do I'll post a link.
But it is cast from the top down. Other rules: weaknesses in the same spell do not affect damage in that spell. And a second cast of the same effect in the same spell replaces the first.
EDIT: Here is the http://www.gamesas.com/index.php?/topic/1173643-enchanted-weapon-effects-applied-in-reverse-order/page__p__17327707#entry17327707 .
That is good to know about the weaknesses.
I discovered that you can't use a custom spell to train more than one skill.
Is it possible to sell spells? I need to recreate many of my custom spells.